Serena \s(e)-re-na\ as a girl's name is pronounced ser-REE-nah, ser-RAY-nah. It is of Latin origin, and the meaning of Serena is "serene, calm". Used by Roman Christians. See also Sirena. Tennis player Serena Williams.
Serena has 13 variant forms: Cerena, Reena, Sarina, Saryna, Sereena, Serenah, Serene, Serenity, Serenna, Serina, Serinah, Serinna and Seryna.