Jacobina \j(a)-cobi-na, jac(o)-bina\ as a girl's name is of Hebrew origin, and the meaning of Jacobina is "he who supplants". Feminine form of Jacob. The name may be related to the romantic cause of the Scottish Jacobite movement of the 17th and 18th centuries to keep Stuart kings on the throne of England.

Jacobina has 11 variant forms: Jackee, Jackie, Jackobina, Jacky, Jacoba, Jacobetta, Jacobette, Jacobine, Jacobyna, Jakobina and Jakobine.