Ephraim \e-ph-raim\ as a boy's name is pronounced EE-frame, EF-ram. It is of Hebrew origin, and the meaning of Ephraim is "fruitful". Biblical: one of Joseph's two sons by his Egyptian wife Asenath. Used mostly in the 18th and 19th centuries. Still a common Jewish given name.
Ephraim has 11 variant forms: Efraim, Efrain, Efrayim, Efrem, Efrim, Efryn, Ephraem, Ephream, Ephrem, Ephrim and Ephrym.