Efrain \e-frain, ef-rain\ as a boy's name is pronounced eh-fra-EEN. It is of Spanish and Hebrew origin, and the meaning of Efrain is "fruitful". Variant of Ephraim. Actor Efrem Zimbalist, Jr.

Efrain has 7 variant forms: Efi, Efraim, Efran, Efrayim, Efrem, Efren and Efrim.

Baby names that sound like Efrain are Efron and Efryn.