Wynona \wyn(o)-na\ as a girl's name is a variant of Winona (Native American Indian), and the meaning of Wynona is "first-born daughter".

The baby name Wynona sounds like Wynonna, Wynnona and Wenona. Other similar baby names are Anona, Annona, Wynne, Wanna, Lynna, Wynn, Winonna, Winonah, Winoena, Winnona and Wenonah.