Layne \la(y)-ne\ as a girl's name (also used as boy's name Layne), is a variant of Laine (English) and Lane (Middle English), and the meaning of Layne is "path, roadway".

The baby name Layne sounds like Layney, Lannie, Lanny, Lanna, Lana, Lyna, Lene, Lainey, Lanae, Lanie, Laney, Laina, Lani, Lianne, Leanne, Leyna, Leone, Liane, Liahne, Lynne, Lynn, Lyn, Lynea, Lynae, Luanne and Luane. Other similar baby names are Dayne, Jayne, Payne and Rayne.