Drena \d-re-na\ as a girl's name is a variant of Andrea (Greek), and the meaning of Drena is "manly, virile".

The baby name Drena sounds like Dreena, Dorena, Drina and Trena. Other similar baby names are Deena, Drea, Arena, Daena, Dena, Duena, Dreda, Irena, Erena and Urena.