Wetherby \we-ther-by, weth(e)-rby\ as a boy's name is of Old English origin, and the meaning of Wetherby is "wether-sheep farm". Place name. A wether is a castrated male sheep, and a bell-wether is a wether which wears a bell and leads other sheep. The surname shows the importance of the wool trade in England.

Wetherby has 5 variant forms: Weatherbey, Weatherbie, Weatherby, Wetherbey and Wetherbie.