Spiridon \s-piri-don, sp(i)-ridon\ as a boy's name is of Greek origin, and the meaning of Spiridon is "basket". Name of a fourth-century Cypriot sheep farmer who became a bishop and a popular Greek saint. Mainly used among Greeks. American Vice President Spiro Agnew.

Spiridon has 7 variant forms: Speero, Spero, Spiridion, Spiro, Spiros, Spyridon and Spyros.