Gene \ge-ne\ as a boy's name (also used as girl's name Gene), is pronounced jeen. It is of Greek origin, and the meaning of Gene is "well-born, noble". Short form of Eugene. Used as an independent name since the late 19th century. Geno is an Italian short form. Actors Gene Kelly, Gene Wilder, Gene Hackman; jazz musician Gene Krupa.

Gene has 3 variant forms: Genio, Geno and Jeno.

Baby names that sound like Gene are Keane, Gayne, Gaine, Gino, Gunn, Gun, June, Kane, Keyne, Keene, Ken and Kenn.