Efisio \e-fi-sio\ as a boy's name is of Italian and Latin origin, and the meaning of Efisio is "Ephesian, from Ephesus". Ephesus was an early Christian community. Saint Paul wrote two of his letters to the Ephesians. The name occurs mostly on the island of Sardinia, where Italian is the main language.

Baby names that sound like Efisio are Avishai, Yves and Ives. Other similar baby names are Efi, Elisha and Eufemio.